Serous Cavity Formation
Pericardial Cavity, Pleural Cavities (2), Peritoneal Cavity
Serous cavities — lined by serous membranes (mesothelium)

• all serous cavities arise from one common embryonic
coelom

• the separate individual cavities found in the adult are formed by

- inward growth of partitions and

- outward excavation into body wall by cavity expansion
Coelom (celom) — horseshoe-shaped cavity bounded by
splanchnopleure and
somatopleure

• the original space between trophoblast and hypoblast is filled by lateral mesenchyme which

subseqnently undergoes cavitation cranially and bilaterally, producing a horseshoe-shaped coelom

betweem
splanchnic mesoderm and
somatic mesoderm

• as a tubular embryo is formed, the coelom is partitioned into intra- and extra-embyonic cavities when

lateral body folds come together along the ventral midline (except at the umbilicus where the

cavities remain connected)

• as the head process grow outward, the cranial loop of coelom (and the adjacent developing heart)

moves ventral to the pharynx and becomes pericardium

• bilateral coelomic cavites are separated by splanchopleure destined to become mediastinum

in the future thorax

• in the future abdomen, splanchnic mesoderm forms dorsal mesentery (ventral mesentery is

largely absent because of the yolk sac)

• surface mesoderm lining the coelom transforms into mesothelium (flattened fibroblasts)
Partitions — grow inward to divide the common intra-embryonic coelom into four serous cavities

• diaphragm formation — the partition between the peritoneal cavity and the two pleural cavities

- a
septum transversum contributes the ventral half of the diaphragm

- bilateral
pleuroperitoneal folds contribute to the dorsal half of the diaphragm

(the above partitions produce only the tendinous center of the adult diaphragm)

•
pleuropericardial folds — bilateral septae grow to separate one pericardial cavity from

the two pleural canals (a common cardinal vein runs in each pleuropericardial fold)
Pleural cavity excavations — as lungs grow, pleural cavities expand, dissecting into

somatic mesoderm of the body wall

• ventral growth establishes the adult pattern: pleural cavities bilateral to the pericardial cavity

somatic mesoderm is carved into:

- medially: mediastinal pleura & fibrous pericardium, and

- laterally: costal parietal pleura & thorax wall

• caudal growth enlarges the diaphragm, adding a muscular rim that will be used for breathing